Department of Pathology, The University of Chicago, 5841 South Maryland Ave, MC 6101, Chicago, IL 60637, USA.
Cancer Prev Res (Phila). 2012 Sep;5(9):1075-7. doi: 10.1158/1940-6207.CAPR-12-0294. Epub 2012 Aug 21.
This perspective examines the report by Zhang and colleagues in this issue of the journal (beginning on page 1081) on the validation and refinement of a set of risk markers for oral premalignant lesion progression that incorporates loss of heterozygosity markers. The perspective also discusses some of the challenges and opportunities of incorporating predictive biomarkers into monitoring and refined enrollment criteria for prevention studies.
本观点审视了张及其同事在本期杂志上(从第 1081 页开始)发表的报告,该报告涉及一组用于口腔癌前病变进展的风险标志物的验证和改进,其中包括杂合性缺失标志物。本观点还讨论了将预测性生物标志物纳入监测和改进预防研究入组标准的一些挑战和机遇。