Singh Bharat, Russell Stuart D, Cheng Alan
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Carnegie 568, Baltimore, MD, 21287, USA.
Curr Treat Options Cardiovasc Med. 2012 Oct;14(5):536-49. doi: 10.1007/s11936-012-0192-7.
Congestive heart failure (CHF) affects more than 5 million people in the United States and is one of the most common reasons for recurrent hospitalizations. Since the majority of admissions related to CHF are secondary to progressively worsening congestion, many clinicians are quick to initiate aggressive diuresis once early signs of impending heart failure develop. These signs are based in large measure on patient-reported symptoms. Unfortunately, recent trials have shown that traditional ambulatory monitoring of heart failure using patient symptoms or body weight do not reduce episodes of decompensated heart failure requiring hospitalization. This has led to great interest in developing monitoring systems that can detect impending episodes of CHF even prior to the development of symptoms. Some of the these systems utilize existing implantable cardioverter defibrillators and cardiac resynchronization therapy devices to monitor electrophysiologic parameters including the presence of ventricular arrhythmias, heart rate variability and even transthoracic impedances. Other more recent developments have focused on more invasive hemodynamic monitoring systems that can measure pressures in the right ventricle, pulmonary arteries and the left atrium. The data on the utility of such systems is limited but encouraging. While none of these systems are currently FDA approved, they have been applied in a number of clinical trials. This paper highlights the currently available monitoring systems for heart failure and reviews the evidence supporting its use.
在美国,充血性心力衰竭(CHF)影响着超过500万人,是反复住院的最常见原因之一。由于大多数与CHF相关的入院是由于充血逐渐恶化所致,一旦出现心力衰竭即将发生的早期迹象,许多临床医生会迅速开始积极利尿治疗。这些迹象很大程度上基于患者报告的症状。不幸的是,最近的试验表明,使用患者症状或体重对心力衰竭进行传统的动态监测并不能减少需要住院治疗的失代偿性心力衰竭发作次数。这引发了人们对开发能够在症状出现之前检测到即将发生的CHF发作的监测系统的极大兴趣。其中一些系统利用现有的植入式心脏复律除颤器和心脏再同步治疗设备来监测电生理参数,包括室性心律失常的存在、心率变异性甚至经胸阻抗。其他最新进展则集中在更具侵入性的血流动力学监测系统上,这些系统可以测量右心室、肺动脉和左心房的压力。关于此类系统效用的数据有限但令人鼓舞。虽然目前这些系统均未获得美国食品药品监督管理局(FDA)的批准,但它们已被应用于多项临床试验中。本文重点介绍了目前可用的心力衰竭监测系统,并综述了支持其使用的证据。