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本文引用的文献

1
Uncovering the benefits of participatory research: implications of a realist review for health research and practice.揭示参与式研究的益处:对健康研究和实践的现实主义综述的启示。
Milbank Q. 2012 Jun;90(2):311-46. doi: 10.1111/j.1468-0009.2012.00665.x.
2
Methodological standards and patient-centeredness in comparative effectiveness research: the PCORI perspective.方法学标准与以患者为中心在比较效果研究中的应用:PCORI 的观点。
JAMA. 2012 Apr 18;307(15):1636-40. doi: 10.1001/jama.2012.466.
3
Person-centered medicine versus personalized medicine: is it just a sophism? A view from chronic pain management.人本医学与个性化医学:这只是诡辩吗?从慢性疼痛管理的角度看。
Psychiatr Danub. 2011 Sep;23(3):246-50.
4
Genomics, health care, and society.基因组学、医疗保健与社会。
N Engl J Med. 2011 Sep 15;365(11):1033-41. doi: 10.1056/NEJMra1010517.
5
Systems medicine and integrated care to combat chronic noncommunicable diseases.系统医学和综合护理防治慢性非传染性疾病。
Genome Med. 2011 Jul 6;3(7):43. doi: 10.1186/gm259.
6
A P5 cancer medicine approach: why personalized medicine cannot ignore psychology.一种针对 P5 癌症药物的方法:为什么个性化医疗不能忽视心理学。
J Eval Clin Pract. 2011 Aug;17(4):594-6. doi: 10.1111/j.1365-2753.2011.01709.x. Epub 2011 Jun 16.
7
The path to personalized medicine.个性化医疗之路。
N Engl J Med. 2010 Jul 22;363(4):301-4. doi: 10.1056/NEJMp1006304. Epub 2010 Jun 15.
8
Does comparative-effectiveness research threaten personalized medicine?比较效果研究是否会对个性化医疗构成威胁?
N Engl J Med. 2009 May 7;360(19):1925-7. doi: 10.1056/NEJMp0901355.

个性化医疗的综合框架:从个体基因组到参与式医疗保健。

An integrated framework of personalized medicine: from individual genomes to participatory health care.

作者信息

Evers Andrea W M, Rovers Maroeska M, Kremer Jan A M, Veltman Joris A, Schalken Jack A, Bloem Bas R, van Gool Alain J

机构信息

Department of Medical Psychology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

出版信息

Croat Med J. 2012 Aug;53(4):301-3. doi: 10.3325/cmj.2012.53.301.

DOI:10.3325/cmj.2012.53.301
PMID:22911520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3428816/
Abstract

Promising research developments in both basic and applied sciences, such as genomics and participatory health care approaches, have generated widespread interest in personalized medicine among almost all scientific areas and clinicians. The term personalized medicine is, however, frequently used without defining a clear theoretical and methodological background. In addition, to date most personalized medicine approaches still lack convincing empirical evidence regarding their contribution and advantages in comparison to traditional models. Here, we propose that personalized medicine can only fulfill the promise of optimizing our health care system by an interdisciplinary and translational view that extends beyond traditional diagnostic and classification systems.

摘要

基础科学和应用科学领域(如基因组学和参与式医疗保健方法)中一些有前景的研究进展,在几乎所有科学领域和临床医生中引发了对个性化医疗的广泛兴趣。然而,“个性化医疗”一词在使用时,常常没有明确的理论和方法背景。此外,迄今为止,与传统模式相比,大多数个性化医疗方法在其贡献和优势方面仍缺乏令人信服的实证依据。在此,我们提出,个性化医疗只有通过一种超越传统诊断和分类系统的跨学科和转化视角,才能实现优化我们医疗保健系统的愿景。