Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical College, Wenzhou 325027, China.
Pediatr Pulmonol. 2013 Apr;48(4):381-9. doi: 10.1002/ppul.22653. Epub 2012 Aug 21.
To exam the relationship between snoring and morbidities of multiple systems in children.
Children with snoring were enrolled and divided into primary snorer (PS) group and obstructive sleep apnea hypopnea syndrome (OSAHS) group based on polysomnography. The healthy children served as the control group. The growth parameters, maxillofacial malformations, blood chemistry, electrocardiogram, and echocardiogram were recorded and intelligence testing was performed in the enrolled children who were ≥6 years old.
The weight and height were similar in the control group (n = 60) and the PS group (n = 63), but lower in the OSAHS group (n = 89; P < 0.001). Occurrence of adenoidal face and dental malocclusion in the OSAHS and the PS group was significantly higher than that in the control group (P < 0.001). Compared with the control group, the OSAHS group had a lower serum high-density lipoprotein cholesterol level, higher low-density lipoprotein cholesterol level; and a possible higher pulmonary artery pressure based on the echocardiogram (P < 0.001). All the above parameters in the PS group were similar to those in the control group. Full-scale IQ and performance IQ of the OSAHS group was lower (P < 0.001), attention deficits were significantly higher in the OSAHS group (P < 0.001), but were similar in the PS group when compared to the control group.
OSAHS in children is associated with delayed growth, maxillofacial malformations, impaired cognitive functions, abnormalities in lipid metabolism, and changes in pulmonary artery pressures. PS children also have higher incidence of maxillofacial malformations but have a normal growth and normal cognitive functions.
研究儿童打鼾与多系统疾病的关系。
根据多导睡眠图将打鼾儿童分为单纯性打鼾（PS）组和阻塞性睡眠呼吸暂停低通气综合征（OSAHS）组，选择同期健康儿童作为对照组。记录所有纳入儿童的生长参数、颌面畸形、血液生化、心电图和超声心动图，≥6 岁的儿童进行智力测试。
对照组（n=60）和 PS 组（n=63）的体重和身高相似，但 OSAHS 组（n=89）的体重和身高均较低（P<0.001）。OSAHS 组和 PS 组腺样体面容和牙列不齐的发生率明显高于对照组（P<0.001）。与对照组相比，OSAHS 组血清高密度脂蛋白胆固醇水平较低，低密度脂蛋白胆固醇水平较高；根据超声心动图，可能肺动脉压较高（P<0.001）。与对照组相比，PS 组的上述参数均无差异。OSAHS 组的全量表智商和操作智商均较低（P<0.001），注意力缺陷明显较高（P<0.001），而 PS 组与对照组相似。
儿童 OSAHS 与生长迟缓、颌面畸形、认知功能障碍、脂代谢异常和肺动脉压改变有关。PS 儿童颌面畸形的发生率也较高，但生长和认知功能正常。
