化感作用和转录的途径得到了简化。

The path to chemotaxis and transcription is smoothened.

机构信息

Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA.

出版信息

Sci Signal. 2012 Aug 21;5(238):pe35. doi: 10.1126/scisignal.2003423.

DOI:10.1126/scisignal.2003423

Abstract

The Hedgehog (Hh) family of secreted proteins governs the development of numerous tissues by regulating the activity of the Gli family of transcription factors. Emerging evidence shows that Hh also functions as a chemoattractant in several processes through a noncanonical pathway independent of Gli-mediated transcription. How Hh-responsive cells execute transcriptional versus chemotactic responses is a key issue. Data now suggest that altered subcellular localization of the transducer Smoothened, which functions in both the canonical and noncanonical pathways, is responsible for eliciting distinct Hh outputs.

摘要

刺猬（Hh）家族的分泌蛋白通过调节 Gli 家族的转录因子的活性来调控许多组织的发育。新出现的证据表明，Hh 还通过非典型途径独立于 Gli 介导的转录在几个过程中充当趋化因子。Hh 反应细胞如何执行转录与趋化反应是一个关键问题。现在的数据表明，转导蛋白 Smoothened 的亚细胞定位改变，该蛋白在经典和非经典途径中均起作用，是引发不同 Hh 输出的原因。