Department of Bioengineering, National University of Singapore, Singapore, Singapore.
PLoS One. 2012;7(8):e42385. doi: 10.1371/journal.pone.0042385. Epub 2012 Aug 17.
Recently, a number of ion channel mutations have been identified in the smooth muscle cells of the human jejunum. Although these are potentially significant in understanding diseases that are currently of unknown etiology, no suitable computational cell model exists to evaluate the effects of such mutations. Here, therefore, a biophysically based single cell model of human jejunal smooth muscle electrophysiology is presented. The resulting cellular description is able to reproduce experimentally recorded slow wave activity and produces realistic responses to a number of perturbations, providing a solid platform on which the causes of intestinal myopathies can be investigated.
最近，在人类空肠的平滑肌细胞中发现了一些离子通道突变。尽管这些突变对于理解目前病因不明的疾病具有潜在的重要意义，但目前还没有合适的计算细胞模型来评估这些突变的影响。因此，本文提出了一种基于生物物理学的人空肠平滑肌电生理学的单细胞模型。所得到的细胞描述能够重现实验记录的慢波活动，并对多种扰动产生现实的反应，为研究肠道肌病的原因提供了一个坚实的平台。
