Department of Interventional Radiology, Fengxian Center Hospital, Shanghai, China.
Eur Rev Med Pharmacol Sci. 2012 Aug;16(8):995-1000.
Hepatocellular carcinoma (HCC) is an aggressive tumor with poor prognosis. Understanding molecular changes in hepatocellular carcinoma should improve identification of risk factors in molecular subtypes and provide potential targets for early detection and therapy.
The present study aimed to analyze the molecular mechanism of the transition from hepatitis C virus (HCV) induced cirrhosis to HCV induced HCC using microarray analysis combined with bioinformatics techniques. METHODS, To accomplish this, we performed the differential coexpression analysis of hepatic gene expression in samples of HCV-cirrhotic patients with and without HCC. Total 465 genes were identified and some of them were used to construct a regulatory network.
Our analysis indicated that several differentially co-express genes might play crucial roles in HCC development, including NA3C2, AHR, MYC, FOXO1 and FOSB. Further analysis predicted these genes might be involved in HCC through pathways of "ribosome", "steroid biosynthesis", "spliceosome" and so on. Moreover, these genes may serve as potential therapeutic targets for the treatment of HCC.
In conclusion, our findings confirm the presence of multiple molecular alterations during HCV-infected HCC hepatocarcinogenesis and indicate the possibility for identifying prognostic factors associated with HCC progression.
肝细胞癌（HCC）是一种预后不良的侵袭性肿瘤。了解肝细胞癌中的分子变化，应能提高对分子亚型中危险因素的识别，并为早期检测和治疗提供潜在的靶点。
本研究旨在通过微阵列分析结合生物信息学技术，分析丙型肝炎病毒（HCV）诱导的肝硬化向 HCV 诱导的 HCC 转变的分子机制。
为了实现这一目标，我们对 HCV 肝硬化患者和无 HCC 患者的肝组织基因表达进行了差异共表达分析。共鉴定出 465 个差异表达基因，其中一些基因用于构建调控网络。
我们的分析表明，一些差异共表达基因可能在 HCC 发展中发挥关键作用，包括 NA3C2、AHR、MYC、FOXO1 和 FOSB。进一步的分析预测，这些基因可能通过“核糖体”、“类固醇生物合成”、“剪接体”等途径参与 HCC。此外，这些基因可能作为 HCC 治疗的潜在治疗靶点。
总之，我们的研究结果证实了 HCV 感染相关 HCC 发生过程中存在多种分子改变，并提示有可能确定与 HCC 进展相关的预后因素。
