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[人工血液循环手术中的特异性蛋白酶血浆吸附]

[Specific proteinase plasma sorption in surgery with artificial blood circulation].

作者信息

Partigulov S A, Bazhenova G E, Oglovlina O G, Belova L A, Vodiasov V D, Sorochinskaia E I, Akchurin R S

出版信息

Vestn Akad Med Nauk SSSR. 1990(12):15-8.

PMID:2291319
Abstract

Cardiosurgery with artificial circulation (AC) is attended with activation of plasma cascade proteolytic systems, which leads to homeostatic disturbances and postoperative complications. AC with the use of specific proteinase plasma sorption in a column with sepharose-immobilized acid-base proteinase inhibitor from human urine prevents activation of proteinase in the plasma. Application of specific plasma sorption facilitates rapid restoration of the plasma protein concentration lowered during AC, improves the course of the postoperative period, and reduces the risk of pulmonary, cardiovascular, and nervous complications.

摘要

体外循环心脏手术会伴随血浆级联蛋白水解系统的激活,这会导致体内稳态紊乱和术后并发症。在使用固定有来自人尿的酸碱蛋白酶抑制剂的琼脂糖柱进行特异性蛋白酶血浆吸附的体外循环中,可防止血浆中蛋白酶的激活。应用特异性血浆吸附有助于快速恢复体外循环期间降低的血浆蛋白浓度,改善术后病程,并降低肺部、心血管和神经并发症的风险。

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