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[接受定期血液透析和腹膜透析患者的氧化应激]

[Oxidative stress in patients on regular hemodialysis and peritoneal dialysis].

作者信息

Vostálová J, Galandáková A, Strebl P, Zadražil J

机构信息

Ústav lékarské chemie a biochemie Lékarské fakulty UP Olomouc.

出版信息

Vnitr Lek. 2012 Jun;58(6):466-72.

Abstract

Hemodialysis and peritoneal dialysis are methods of blood purification, which partially replaced excretory renal function in patients with chronic renal failure, which was depleted regime, dietary and pharmaco-therapeutic remedy, and who are not eligible for kidney transplantation. Both two methods are accompanied by increased oxidative stress. In peritoneal dialysis particularly the composition of dialysis solution contributes to oxidative stress. In extracorporeal hemodialysis the oxidative stress is associated with the character of hemodialysis membranes, non-specific loss of low molecular weight antioxidants, activation of leukocytes (oxidative burst), feroteraphy, supplementation with low molecular weight antioxidants and other factors. To improve and maintain the quality of life of dialysis patients, the continuous monitoring of oxidative stress-related parameters as non-traditional risk factors for cardiovascular complications development is suitable.

摘要

血液透析和腹膜透析是血液净化方法,部分替代了慢性肾衰竭患者的肾脏排泄功能,这些患者采用了低蛋白饮食和药物治疗方案,且不适合进行肾移植。这两种方法都会增加氧化应激。在腹膜透析中,特别是透析液的成分会导致氧化应激。在体外血液透析中,氧化应激与血液透析膜的特性、低分子量抗氧化剂的非特异性损失、白细胞的激活(氧化爆发)、铁疗法、低分子量抗氧化剂的补充以及其他因素有关。为了改善和维持透析患者的生活质量,持续监测作为心血管并发症发生的非传统危险因素的氧化应激相关参数是合适的。

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