Department of Psychology, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK.
J Clin Exp Neuropsychol. 2012;34(9):989-98. doi: 10.1080/13803395.2012.712676. Epub 2012 Aug 23.
Studies reporting on the cognitive abilities of men and women with Alzheimer's disease (AD) are surprisingly rare. We carried out a meta-analysis of neurocognitive data from 15 studies (n = 828 men; 1,238 women), which revealed a consistent male advantage on verbal and visuospatial tasks and tests of episodic and semantic memory. Moderator regression analyses showed that age, education level, and dementia severity did not significantly predict the male advantage. Reasons posited for this advantage include a reduction of estrogen in postmenopausal women, sex differences in AD pathology, and greater cognitive reserve in men.
研究报告阿尔茨海默病（AD）男性和女性认知能力的情况非常少见。我们对 15 项研究的神经认知数据进行了荟萃分析（n = 828 名男性；1238 名女性），结果表明男性在言语和视空间任务以及情景和语义记忆测试中具有一致的优势。调节回归分析表明，年龄、教育水平和痴呆严重程度并不能显著预测男性的优势。这种优势的原因包括绝经后女性雌激素的减少、AD 病理的性别差异以及男性的认知储备更大。
