Jakobsen J
Department of Neurology, Aarhus University Hospital, Denmark.
Acta Neurol Scand. 1990 Dec;82(6):392-5. doi: 10.1111/j.1600-0404.1990.tb03323.x.
Eighteen MS patients with visual acuity of 20/30 or better and without recent visual complaints, and 14 age- and sex-matched controls were studied by TV pupillography. The response amplitude and the maximum rate of pupillary constriction or dilation of the light, dark, accommodation and ciliospinal reflexes were unchanged. The latency of the pupillary light response (PLR), however, was prolonged and closely related to walking performance (R = 0.76; p less than 0.001). No relationship was established between PLR latency and previous history of optic neuritis or latency of the VEP. It is concluded that MS patients with preserved visual acuity have only discrete autonomic pupillary disturbances and that the PLR delay is related to disease progression.
对18名视力为20/30或更好且近期无视觉主诉的多发性硬化症（MS）患者，以及14名年龄和性别匹配的对照者进行了电视瞳孔描记术研究。光、暗、调节和睫脊反射的反应幅度以及瞳孔收缩或扩张的最大速率均未改变。然而，瞳孔对光反应（PLR）的潜伏期延长，且与行走能力密切相关（R = 0.76；p < 0.001）。PLR潜伏期与既往视神经炎病史或视觉诱发电位（VEP）潜伏期之间未建立联系。得出的结论是，视力保持良好的MS患者仅有离散的自主神经瞳孔功能障碍，且PLR延迟与疾病进展有关。
