Safai-Kutti S
Pediatric Clinic, Biskopsgården, Göteborg, Sweden.
Acta Psychiatr Scand Suppl. 1990;361:14-7.
There is evidence to suggest that zinc (Zn) deficiency may be involved in the pathogenesis of anorexia nervosa (AN). In an open study of 20 females, aged 14-26 years, afflicted with AN the effect of oral zinc supplementation was investigated. In each case the diagnosis of AN was based on the criteria of DSM-III-R. After a careful history, complete physical examination and laboratory screening the subjects were started on 45-90 mg of Zn2+, as zinc sulfate, (SolvezinkR, Tika, Sweden) per day. During a follow-up period of 8-56 months 17 patients increased their body weight by more than 15%. The maximum gradual weight gain of 57% was encountered in one patient after 24 months of zinc therapy. The most rapid weight gain was recorded in a patient who increased her body weight by 24% over a period of 3 months. After the institution of zinc, weight loss was not registered in any of our patients. In 13 subjects the menstruation returned 1-17 months after the initiation of zinc therapy. None of our patients developed bulimia. The design of an ongoing multicenter placebo-controlled clinical trial of zinc supplementation to patients with AN is described.
有证据表明锌（Zn）缺乏可能与神经性厌食症（AN）的发病机制有关。在一项针对20名年龄在14至26岁患有AN的女性的开放性研究中，调查了口服补锌的效果。在每种情况下，AN的诊断均基于DSM-III-R标准。经过详细的病史询问、全面的体格检查和实验室筛查后，受试者开始每天服用45至90毫克的Zn2 +，以硫酸锌（SolvezinkR，Tika，瑞典）的形式。在8至56个月的随访期内，17名患者体重增加超过15%。一名患者在接受锌治疗24个月后体重最大逐渐增加了57%。体重增加最快的是一名患者，在3个月内体重增加了24%。开始补锌后，我们的患者均未出现体重减轻。13名受试者在开始锌治疗后1至17个月月经恢复。我们的患者均未出现贪食症。本文描述了一项正在进行的针对AN患者补锌的多中心安慰剂对照临床试验的设计。
