Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO 63110, USA.
Obstet Gynecol. 2012 Jul;120(1):130-5. doi: 10.1097/AOG.0b013e318259589c.
To estimate the effects of obesity on the duration and progression of the first stage of labor in a predominantly obese population and estimate the dose-effect with increasing classes of obesity.
We performed a retrospective cohort study of labor progression among 5,204 consecutive parturients with singleton term pregnancies (37 weeks of gestation or more) and vertex presentation who completed the first stage of labor. Two comparison groups were defined by body mass index (BMI) less than 30 (n=2,413) or 30 or more (n=2,791). Repeated-measures analysis with polynomial modeling was used to construct labor curves. The duration and progression among women with BMIs less than 30 and BMIs of 30 or more were compared in a multivariable interval-censored regression model adjusting for parity, type of labor onset, race, and birth weight more than 4,000 g.
The labor curves indicate longer duration and slower progression of the first stage of labor among women with BMIs of 30 or more for both nulliparous and multiparous women. Multivariable interval-censored regression analysis confirmed significantly longer duration (4-10 cm: 4.7 compared with 4.1 hours, P<.01) and slower progression of cervical dilation from 4 to 6 cm (2.2 compared with 1.9 hours, P<.01 with a range of 0.5-10.0 hours) among women with BMIs of 30 or more after adjusting for confounders.
The overall duration is longer and progression of the early part of the first stage of labor is slower in obese women. This suggests that obesity should be considered in defining norms for management of labor, particularly in the early part of the first stage.
在肥胖人群中,估计肥胖对第一产程持续时间和进展的影响,并估计随着肥胖程度的增加,这种剂量效应。
我们对 5204 例连续的足月单胎妊娠(37 周或以上)且头位的产妇进行了一项回顾性队列研究,这些产妇完成了第一产程。通过体质量指数(BMI)将两组进行比较,BMI 小于 30(n=2413)或 30 或更高(n=2791)。使用多项式模型的重复测量分析来构建劳动曲线。在多变量间隔censored 回归模型中,调整了产次、分娩开始类型、种族和出生体重超过 4000 g 后,比较了 BMI 小于 30 和 BMI 为 30 或更高的妇女之间的第一产程持续时间和进展情况。
劳动曲线表明,对于初产妇和经产妇,BMI 为 30 或更高的妇女第一产程的持续时间更长,进展更缓慢。多变量间隔 censored 回归分析证实,在调整混杂因素后,BMI 为 30 或更高的妇女第一产程持续时间明显更长(4-10 cm:4.7 小时比 4.1 小时,P<.01),从 4 厘米到 6 厘米的宫颈扩张进展更缓慢(2.2 小时比 1.9 小时,P<.01,范围为 0.5-10.0 小时)。
肥胖妇女的总产程较长,第一产程早期进展较慢。这表明,在定义分娩管理的正常范围时,应考虑肥胖因素,特别是在第一产程的早期。