上皮性卵巢癌的 10 年相对生存率。

Ten-year relative survival for epithelial ovarian cancer.

机构信息

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.

出版信息

Obstet Gynecol. 2012 Sep;120(3):612-8. doi: 10.1097/AOG.0b013e318264f794.

DOI:10.1097/AOG.0b013e318264f794

PMID:22914471

Abstract

OBJECTIVE

Most patients with epithelial ovarian cancer who are alive at 5 years have active disease. Thus, 10-year survival rather than 5-year survival may be a more appropriate endpoint. Relative survival adjusts for the general survival of the United States population for that race, sex, age, and date at which the diagnosis was coded. Our objective was to estimate relative survival in epithelial ovarian cancer over the course of 10 years.

METHODS

Using the Surveillance, Epidemiology and End Results 1995-2007 database, epithelial ovarian cancer cases were identified. Using the actuarial life table method, relative survival over the course of 10 years was calculated, stratified by stage, classification of residence, surgery as the first course of treatment, race, and age.

RESULTS

There were 40,692 patients who met inclusion criteria. The overall relative survival was 65%, 44%, and 36% at 2, 5, and 10 years, respectively. The slope of decline in relative survival was reduced for years 5-10 as compared with years 1-5 after diagnosis. Relative survival at 5 years was 89%, 70%, 36%, and 17%, and at 10 years relative survival was 84%, 59%, 23%, and 8% for stages I, II III, and IV, respectively. At all stages, patients with nonsurgical primary treatment and those with advanced age had reduced relative survival.

CONCLUSIONS

The 10-year relative survival for stage III is higher than expected. This information provides the physician and the patient with more accurate prognostic information.

摘要

目的

大多数存活 5 年的上皮性卵巢癌患者均有活跃疾病。因此，10 年生存率可能比 5 年生存率更合适。相对生存率根据美国特定种族、性别、年龄和诊断编码日期的总体生存率进行调整。我们的目的是估计上皮性卵巢癌在 10 年内的相对生存率。

方法

使用监测、流行病学和最终结果 1995-2007 数据库，确定上皮性卵巢癌病例。使用 actuarial life table 方法，按分期、居住分类、作为初始治疗的手术、种族和年龄分层，计算 10 年内的相对生存率。

结果

符合纳入标准的患者共有 40692 例。总体相对生存率分别为 2 年、5 年和 10 年时的 65%、44%和 36%。与诊断后 1-5 年相比，诊断后 5-10 年的相对生存率下降速度放缓。5 年时的相对生存率分别为 89%、70%、36%和 17%，10 年时的相对生存率分别为 84%、59%、23%和 8%，分别为 I 期、II 期、III 期和 IV 期。在所有分期中，非手术初始治疗的患者和年龄较大的患者的相对生存率降低。