Pritlove Cheryl, Capone Geremy, Ramasamy Mathankki, Avery Lisa, Fierini Daniela, Ferguson Sarah E, Han Kathy, Jones Jennifer M
Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, ON M5C 2T2, Canada.
Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A, Canada.
Nutrients. 2024 Dec 6;16(23):4227. doi: 10.3390/nu16234227.
BACKGROUND/OBJECTIVES: Pelvic radiotherapy (RT) improves survival in gynecologic cancer patients but often results in gastrointestinal (GI) toxicity, affecting quality of life. Standard nutrition guidance lacks specificity for these survivors, complicating dietary choices. To address this gap, the EDIBLE intervention was developed to offer structured dietary self-management skills to alleviate RT-induced GI toxicity.
We conducted a single-arm mixed-methods pilot of the EDIBLE intervention among post-treatment gynecologic cancer survivors to assess its feasibility, acceptability, and preliminary effects on GI symptoms, knowledge, and self-efficacy, with measures at baseline (T1), post-intervention (T2), and after 3 months (T3).
Qualitative interviews supported strong perceptions of intervention feasibility; however, the recruitment (32%) and retention (72%) rates were modest, indicating that alternate formats for program delivery may be needed to make it more accessible. The acceptability of the EDIBLE intervention garnered especially high ratings on measures of satisfaction and utility, with program improvements largely rallying around a desire for increased in-class sessions and program expansion. Statistically significant improvements were observed at the three-month mark (T3), such as enhanced confidence in culinary practices, increased knowledge and skills with regard to managing GI side effects, and improvements in bowel and GI symptoms.
The results suggest EDIBLE is acceptable, improving GI symptoms and self-efficacy; however, moderate recruitment rates indicate refinement is needed. A randomized control trial and cost-effectiveness analysis is needed to confirm effectiveness and scalability.
背景/目的：盆腔放疗（RT）可提高妇科癌症患者的生存率，但常导致胃肠道（GI）毒性，影响生活质量。标准的营养指导对这些幸存者缺乏针对性，使饮食选择变得复杂。为填补这一空白，开发了EDIBLE干预措施，以提供结构化的饮食自我管理技能，减轻放疗引起的胃肠道毒性。
我们对治疗后的妇科癌症幸存者进行了一项单臂混合方法的EDIBLE干预试点，以评估其可行性、可接受性以及对胃肠道症状、知识和自我效能的初步影响，在基线（T1）、干预后（T2）和3个月后（T3）进行测量。
定性访谈支持了对干预可行性的强烈认知；然而，招募率（32%）和保留率（72%）适中，表明可能需要采用其他形式的项目交付方式，使其更容易获得。EDIBLE干预的可接受性在满意度和效用测量方面获得了特别高的评分，项目改进主要围绕增加课堂课程和项目扩展的愿望。在三个月时（T3）观察到了统计学上的显著改善，例如烹饪实践的信心增强、管理胃肠道副作用的知识和技能增加，以及肠道和胃肠道症状的改善。
结果表明EDIBLE是可接受的，可改善胃肠道症状和自我效能；然而，中等的招募率表明需要改进。需要进行随机对照试验和成本效益分析，以确认有效性和可扩展性。
