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血管内治疗:球囊血管成形术与尼莫地平动脉内注射治疗动脉瘤性蛛网膜下腔出血后药物难治性脑血管痉挛的比较

Endovascular treatment: balloon angioplasty versus nimodipine intra-arterial for medically refractory cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

作者信息

Aburto-Murrieta Yolanda, Marquez-Romero Juan M, Bonifacio-Delgadillo Dulce, López Iván, Hernández-Curiel B

机构信息

Departamento de Terapia Endovascular, Instituto Nacional de Neurología y Neurología, Insurgentes Sur, Mexico.

出版信息

Vasc Endovascular Surg. 2012 Aug;46(6):460-5. doi: 10.1177/1538574412454585.

Abstract

Cerebral vasospasm (CV) accounts significant morbimortality after aneurysmal subarachnoid hemorrhage. The objective of this study was to compare the clinical outcome of patients with CV treated by 2 endovascular procedures: intra-arterial nimodipine angioplasty (IANA) and balloon angioplasty (BA). Between 2008 and June 2011, we performed 22 IANA and 8 BA in 30 patients. The mean age was 44 years and 60% was female. In 17 patients, the treatment was clipping, whereas 13 underwent coil treatment. The CV was severe in 63%, moderate in 30%, and mild in 7%. Good outcome between 2 groups was similar (P = .36). The clinical outcome according to the subgroups of CV severity and modality treatment was equivalent (P = .22). Mortality at 3 months was 16% and 20% at 1 year. We did not find differences in the clinical outcome despite the fact that both techniques produce adequate angiographic resolution of CV.

摘要

脑动脉痉挛(CV)是动脉瘤性蛛网膜下腔出血后导致严重病残率和死亡率的重要原因。本研究的目的是比较采用两种血管内介入治疗方法治疗CV患者的临床疗效:动脉内尼莫地平血管成形术(IANA)和球囊血管成形术(BA)。2008年至2011年6月期间,我们对30例患者实施了22例IANA和8例BA。平均年龄为44岁,60%为女性。17例患者接受了夹闭治疗,13例接受了弹簧圈治疗。CV严重程度为重度的占63%,中度的占30%,轻度的占7%。两组间良好预后情况相似(P = 0.36)。根据CV严重程度亚组和治疗方式得出的临床疗效相当(P = 0.22)。3个月时死亡率为16%,1年时为20%。尽管两种技术均能使CV在血管造影上获得足够的改善,但我们未发现临床疗效存在差异。

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