Surveillance Research, American Cancer Society, 250 Williams Street, NW, Atlanta, GA 30303-1002, USA.
Breast Cancer Res Treat. 2012 Oct;135(3):867-73. doi: 10.1007/s10549-012-2214-2. Epub 2012 Aug 23.
Previous studies have reported that the prevalence of ER-negative tumors in breast cancer patients is much higher in black women than in white women in the US. Herein, we examine whether the proportion (prevalence) in Africa-born black breast cancer patients residing in the US is similar to those in US-born black patients. We obtained information on invasive female breast cancers diagnosed during 1996-2008 in 17 Surveillance Epidemiology and End Results cancer registries according to select place of birth: Western-Africa-born, Eastern-Africa-born, Jamaica-born, and US-born blacks and US-born whites. The majority of Western-Africa-born and Eastern-Africa-born blacks were from Nigeria (64 %) and Ethiopia (74 %), respectively. We examined group variations in ER status using Chi-squared tests and the prevalence of ER-negative tumors in Africa-born blacks compared to US-born blacks, expressed as prevalence ratio (PRR), using multivariable regression models. The prevalence of ER-negative tumors significantly varied from 22.0 % (n = 41/186) in Eastern-Africa-born to 32.9 % (n = 47/143) in Western-Africa-born blacks. After adjustment for differences in age at diagnosis and other covariates, compared to US-born blacks, the prevalence was similar in Western-Africa-born (PRR = 0.87; 95 % CI 0.70-1.08) and Jamaica-born blacks (PRR = 0.88; 95 % CI 0.74-1.03), but significantly lower in Eastern-Africa-born blacks (PRR = 0.58; 95 % CI 0.44-0.75). Notably, the ER-negative prevalence in Eastern-Africa-born black was comparable to the US-born whites with breast cancer. Our findings highlight the heterogeneity of breast cancer among black women in the US, which should be considered in future studies of hormone receptor status in these women.
先前的研究报告称，在美国，黑人女性乳腺癌患者中雌激素受体阴性肿瘤的患病率远高于白人女性。在此，我们研究了在美国出生的黑人和非洲出生的黑人群体中，雌激素受体阴性肿瘤的比例（患病率）是否相似。我们根据选择的出生地，从 1996 年至 2008 年在 17 个监测、流行病学和最终结果癌症登记处获取了诊断为浸润性女性乳腺癌的信息：西非出生、东非出生、牙买加出生和美国出生的黑人和美国出生的白人。大多数西非出生和东非出生的黑人分别来自尼日利亚（64%）和埃塞俄比亚（74%）。我们使用卡方检验检查了 ER 状态的组间差异，并使用多变量回归模型检查了非洲出生的黑人中 ER 阴性肿瘤的患病率与美国出生的黑人相比的患病率比（PRR）。ER 阴性肿瘤的患病率从东非出生的 22.0%（n=41/186）到西非出生的 32.9%（n=47/143）显著不同。调整诊断时的年龄差异和其他协变量后，与美国出生的黑人相比，西非出生（PRR=0.87；95%CI 0.70-1.08）和牙买加出生（PRR=0.88；95%CI 0.74-1.03）的黑人患病率相似，但东非出生的黑人患病率明显较低（PRR=0.58；95%CI 0.44-0.75）。值得注意的是，东非出生的黑人的 ER 阴性患病率与美国出生的白人乳腺癌患者相似。我们的研究结果强调了美国黑人女性乳腺癌的异质性，在这些女性的激素受体状态的未来研究中应考虑到这一点。
