Fortier-Beaulieu M, Thomine E, Mitrofanof P, Lauret P, Hemet J
Clinique Dermatologique, Hôpital Charles Nicolle, CHU de Rouen.
Ann Pediatr (Paris). 1990 Dec;37(10):673-6.
Clinicopathological findings and outcomes in ten pediatric cases of lichen sclerosus and atrophicus of the foreskin are reported. This well-defined entity usually presents as acquired sclerous phimosis. Diagnosis rests on histologic studies of biopsy specimens. Pathologic features change during the course of disease and are useful for selecting the most appropriate therapy. Local corticosteroid therapy may be helpful in early disease. However, circumcision is usually required for advanced disease, failure of medical therapy or prevention of squamous cell carcinoma. Pathophysiology is discussed. The incidence of this condition seems to be underestimated. Possible connections with diabetes mellitus and other conditions are reviewed.
报告了10例小儿包皮硬化萎缩性苔藓的临床病理结果及转归。这种明确的疾病通常表现为后天性硬化性包茎。诊断依赖于活检标本的组织学研究。病理特征在疾病过程中会发生变化,有助于选择最合适的治疗方法。局部皮质类固醇治疗在疾病早期可能有帮助。然而,对于晚期疾病、药物治疗失败或预防鳞状细胞癌,通常需要进行包皮环切术。文中讨论了其病理生理学。这种疾病的发病率似乎被低估了。文中回顾了与糖尿病和其他疾病可能存在的关联。