Masse J, Terol A, Chauvet A
Laboratoire de Chimie Générale et Minérale, Faculté de Pharmacie, Montpellier.
Ann Pharm Fr. 1990;48(2):57-69.
Thermogravimetry, differential scanning calorimetry, thermomicroscopy, transparency measure permit drug quality control: knowledge of solvated or unsolvated mole, thermal stability, identification of crystalline form (polymorphism) quick determination of total impurity with graphs. These methods can be used for therapeutic activity optimization of very weakly soluble drugs: research of the polymorph showing the best kinetic dissolution, establishment of phase diagram drug/inert substance by example for determination invariant composition particularly eutectic for which the drug solubility is increased.
