探讨十种多瘤病毒和两种疱疹病毒在乳腺癌中的流行情况。
Exploring the prevalence of ten polyomaviruses and two herpes viruses in breast cancer.
机构信息
Queensland Institute of Medical Research, Department of Population Health, Herston, Brisbane, Queensland, Australia.
出版信息
PLoS One. 2012;7(8):e39842. doi: 10.1371/journal.pone.0039842. Epub 2012 Aug 15.
Several different viruses have been proposed to play a role in breast carcinogenesis. The aim of this study was to investigate the prevalence of a subset of viruses in breast cancer tissue. We investigated the prevalence of 12 DNA viruses: EBV and CMV from the Herpesviridae family and SV40, BKV, JCV, MCV, WUV, KIV, LPV, HPyV6, HPyV7, and TSV from the Polyomaviridae family in 54 fresh frozen breast tumour specimens. Relevant clinical data and basic lifestyle data were available for all patients. The tissue samples were DNA extracted and real-time PCR assays were used for viral detection.The highest prevalence, 10% (5/54), was found for EBV. MCV, HPyV6, and HPyV7 were detected in single patient samples (2% each), while WUV, KIV, JCV, BKV, LPV, SV40, TSV and CMV were not detected in the 54 breast cancer specimens analysed here. Further investigations are needed to elucidate the potential role of viruses, and particularly EBV, in breast carcinogenesis.
已有几种不同的病毒被提出在乳腺癌发生中发挥作用。本研究旨在调查一组病毒在乳腺癌组织中的流行情况。我们调查了 54 个新鲜冷冻乳腺癌标本中 12 种 DNA 病毒的流行情况：疱疹病毒科的 EBV 和 CMV，以及多瘤病毒科的 SV40、BKV、JCV、MCV、WUV、KIV、LPV、HPyV6、HPyV7 和 TSV。所有患者均有相关临床数据和基本生活方式数据。组织样本提取 DNA，使用实时 PCR 检测病毒。结果发现 EBV 的流行率最高，为 10%（5/54）。MCV、HPyV6 和 HPyV7 在单个患者样本中检测到（各占 2%），而 WUV、KIV、JCV、BKV、LPV、SV40、TSV 和 CMV 未在分析的 54 个乳腺癌标本中检测到。需要进一步研究以阐明病毒，特别是 EBV，在乳腺癌发生中的潜在作用。
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