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内颈动脉闭塞患者对侧颈动脉支架置入术后脑血流动力学获益。

Cerebral hemodynamic benefits after contralateral carotid artery stenting in patients with internal carotid artery occlusion.

机构信息

Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan.

出版信息

AJNR Am J Neuroradiol. 2013 Mar;34(3):616-21. doi: 10.3174/ajnr.A3250. Epub 2012 Aug 23.

Abstract

CEA contralateral to an ICA occlusion is considered a surgical risk, and CAS may be an alternative for these patients. Our goal was to examine whether CAS improves cerebral hemodynamics on the treated side and on the side of the ICA occlusion, on the basis of measurement of CBF and CVR by using SPECT. The subjects were 8 patients who underwent contralateral CAS. Resting CBF and CVR to acetazolamide were measured by using (123)I-IMP SPECT before and chronically (3-6 months) after CAS. Resting CBF was also measured immediately (<2 hours) after CAS by using (123)I-IMP SPECT. There were no significant differences in resting CBF in both hemispheres immediately after CAS. However, resting CBF and CVR both significantly increased in the chronic period in both hemispheres. Contralateral CAS in patients with ICA occlusion resulted in cerebral hemodynamic improvement on the treated side and on the side of ICA occlusion.

摘要

对 ICA 闭塞同侧的 CEA 被认为是一种手术风险,而 CAS 可能是这些患者的替代治疗方法。我们的目的是通过 SPECT 测量 CBF 和 CVR,来检测 CAS 是否能改善治疗侧和 ICA 闭塞侧的脑血流动力学。该研究纳入了 8 例接受对侧 CAS 的患者。在 CAS 之前和之后(3-6 个月),使用 (123)I-IMP SPECT 测量静息 CBF 和乙酰唑胺的 CVR。在 CAS 后立即(<2 小时),也使用 (123)I-IMP SPECT 测量静息 CBF。CAS 后即刻两侧半球的静息 CBF 没有显著差异。然而,在慢性期两侧半球的静息 CBF 和 CVR 均显著增加。ICA 闭塞患者的对侧 CAS 导致治疗侧和 ICA 闭塞侧的脑血流动力学改善。

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