Dämmrich M, Thomssen C, Hillemanns P, Kreipe H
Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
Pathologe. 2012 Sep;33(5):424-9. doi: 10.1007/s00292-012-1596-6.
In breast surgery intraoperative frozen sections for the diagnosis of malignancy has lost impact and has largely been replaced by preoperative core needle biopsies. Nevertheless, there is still need for immediate pathological investigation of native breast tissue during surgery due to three reasons: (1) macroscopic and microscopic evaluation of resection margins, (2) the histological analysis of sentinel lymph nodes in order to circumvent secondary axillary surgery and (3) the preparation of native tissue for tumor banking or measurement of biomarkers. Because histology provides only a facultative component of immediate pathological examination of breast specimens during surgery, the term frozen section does not seem to be appropriate anymore. Intraoperative evaluation of resection specimens by pathologists provides surgically relevant information immediately, guarantees standardized preparation and fixation of specimens and enables tissue banking of native tissue for assessment of biological markers.
在乳腺外科手术中，用于诊断恶性肿瘤的术中冰冻切片已失去影响力，很大程度上已被术前粗针活检所取代。然而，由于三个原因，手术期间仍需要对乳腺原生组织进行即时病理检查：（1）对手术切缘进行宏观和微观评估；（2）对前哨淋巴结进行组织学分析，以避免二次腋窝手术；（3）为肿瘤样本库准备原生组织或测量生物标志物。由于组织学只是手术期间乳腺标本即时病理检查的一个可选组成部分，“冰冻切片”这个术语似乎不再合适。病理学家对手术切除标本进行术中评估可立即提供与手术相关的信息，保证标本的标准化制备和固定，并能够对原生组织进行样本库保存以评估生物标志物。
