MCM结构与力学：我们从古菌MCM中学到的知识。

MCM structure and mechanics: what we have learned from archaeal MCM.

作者信息

Slaymaker Ian M, Chen Xiaojiang S

机构信息

Molecular and Computational Biology, University of Southern California, Los Angeles, CA, 90089, USA.

出版信息

Subcell Biochem. 2012;62:89-111. doi: 10.1007/978-94-007-4572-8_6.

DOI:10.1007/978-94-007-4572-8_6

PMID:22918582

Abstract

Minichromosome maintenance (MCM) complexes have been identified as the primary replicative helicases responsible for unwinding DNA for genome replication. The focus of this chapter is to discuss the current structural and functional understanding of MCMs and their role at origins of replication, which are based mostly on the studies of MCM proteins and MCM complexes from archaeal genomes.

摘要

微小染色体维持（MCM）复合物已被确定为负责解开DNA以进行基因组复制的主要复制解旋酶。本章的重点是讨论目前对MCM的结构和功能的理解以及它们在复制起点的作用，这些内容大多基于对古细菌基因组中MCM蛋白和MCM复合物的研究。