Bell Stephen D
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK,
Subcell Biochem. 2012;62:59-69. doi: 10.1007/978-94-007-4572-8_4.
The initiation of DNA replication in most archaeal genomes is mediated by proteins related to eukaryotic Orc1 and Cdc6. Archaeal replication origins have been mapped and their interactions with Orc1/Cdc6 proteins have been characterized at the biochemical level. Structural and biophysical studies have revealed the basic rules of sequence recognition by archaeal initiators.
大多数古菌基因组中DNA复制的起始是由与真核生物Orc1和Cdc6相关的蛋白质介导的。古菌复制起点已被定位，并且它们与Orc1/Cdc6蛋白质的相互作用已在生化水平上得到表征。结构和生物物理研究揭示了古菌起始蛋白序列识别的基本规则。
