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抑郁症的遗传基础。

The genetic basis of depression.

作者信息

Hodgson Karen, McGuffin Peter

机构信息

MRC SGDP Centre, Institute of Psychiatry, King's College London, UK.

出版信息

Curr Top Behav Neurosci. 2013;14:81-99. doi: 10.1007/7854_2012_225.

Abstract

Since the publication of the working draft of the human genome just over a decade ago, there have been dramatic advances in our understanding of the role genetics play in both normal human functioning as well as in disease. The identification of genes, which influence an individual's susceptibility to depression, is not only an intriguing scientific endeavour in its own right, but further, if a gene can be confidently implicated in depression, then this could shed light on the aetiological processes involved in the disease. Moreover, a genetic association with depression may identify targets for consideration in the development of novel treatments for the illness. This chapter will summarise the current research into the genetic basis of depression. A number of genes of interest have been highlighted, although a genetic variant, that is unequivocally associated with increased risk for the disease, is yet to be identified. However, technologies and methodologies are evolving rapidly, and genetic approaches have helped shape how we conceptualise depression as an illness.

摘要

自十多年前人类基因组工作草图公布以来,我们对遗传学在人类正常功能以及疾病中所起作用的理解取得了巨大进展。确定那些影响个体患抑郁症易感性的基因,本身不仅是一项引人入胜的科学探索,而且更进一步地说,如果一个基因能够被确切地认定与抑郁症有关,那么这可能会揭示该疾病所涉及的病因学过程。此外,与抑郁症的基因关联可能会为该疾病新疗法的开发确定可供考虑的靶点。本章将总结目前对抑郁症遗传基础的研究。尽管尚未确定一个与该疾病风险增加明确相关的基因变异,但已经突出了一些感兴趣的基因。然而,技术和方法正在迅速发展,并且遗传学方法已经有助于塑造我们将抑郁症视为一种疾病的概念。

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