Couet W, Istin B, Decourt J P, Ingrand I, Girault J, Fourtillan J B
Br J Clin Pharmacol. 1990 Oct;30(4):616-20. doi: 10.1111/j.1365-2125.1990.tb03822.x.
Pharmacokinetic interaction between ponsinomycin-nicoumalone was studied in six subjects who received an 8 mg oral dose of racemic nicoumalone alone and 4 days into an oral regimen of ponsinomycin 800 mg twice daily. The concentrations of R(+) and S(-)-nicoumalone in plasma were measured using a stereospecific h.p.l.c. assay. The disposition characteristics of nicoumalone enantiomers in the control phase of this study were similar to those reported previously with the exception of the data for one subject whose oral clearance for S(-)-nicoumalone was seven times lower than those in the other subjects. A statistically significant effect of ponsinomycin on the kinetics of R(+) and S(-)-nicoumalone was not demonstrated.
在6名受试者中研究了竹桃霉素与烟曲霉素之间的药代动力学相互作用。这些受试者单独口服8 mg消旋烟曲霉素，且在每天两次口服800 mg竹桃霉素的治疗方案进行4天后。使用立体特异性高效液相色谱法测定血浆中R(+)和S(-)-烟曲霉素的浓度。本研究对照阶段烟曲霉素对映体的处置特征与先前报道的相似，但有一名受试者除外，该受试者S(-)-烟曲霉素的口服清除率比其他受试者低7倍。未证明竹桃霉素对R(+)和S(-)-烟曲霉素的动力学有统计学显著影响。
