Department of Surgery, University of Wisconsin, 1111 Highland Ave., Madison, WI 53705, USA.
Cardiovasc Res. 2012 Dec 1;96(3):363-71. doi: 10.1093/cvr/cvs276. Epub 2012 Aug 22.
It has been appreciated over the past two decades that arterial remodelling, in addition to intimal hyperplasia, contributes significantly to the degree of restenosis that develops following revascularization procedures. Remodelling appears to be an adventitia-based process that is contributed to by multiple factors including cytokines and growth factors that regulate extracellular matrix or phenotypic transformation of vascular cells including myofibroblasts. In this review, we summarize the currently available information from animal models as well as clinical investigations regarding arterial remodelling. The factors that contribute to this process are presented with an emphasis on potential therapeutic methods to enhance favourable remodelling and prevent restenosis.
在过去的二十年中，人们已经认识到，除内膜增生外，动脉重构对血管再通术后再狭窄的程度有重要影响。重构似乎是一种基于血管外膜的过程，由多种因素共同作用，包括调节细胞外基质的细胞因子和生长因子，以及血管细胞（包括平滑肌细胞）的表型转化。在这篇综述中，我们总结了目前在动物模型和临床研究中关于动脉重构的信息。本文重点介绍了促进有利重构和预防再狭窄的潜在治疗方法。
