Corić Lejla, Vargek-Solter Vesna, Supanc Visnja, Miskov Snjezana, Drnasin Sara, Sabolek Karla, Bedek Darko, Demarin Vida
University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Acta Clin Croat. 2012 Mar;51(1):89-92.
Creutzfeldt-Jakob disease is the most common form of human prion diseases. A 57-year-old woman was transferred to our Department from a local hospital, where she had been treated for two weeks due to consciousness disorders and convulsive epileptic attacks that progressed to refractory status epilepticus. Electroencephalography showed diffuse spike-wave complex discharges and development of nonconvulsive status epilepticus. The causes of metabolic encephalopathy and paraneoplastic syndrome were ruled out. A combination of clinical features and findings of diagnostic procedures including electroencephalography, biomarkers in the cerebrospinal fluid and magnetic resonance imaging suggested with great probability that the patient was affected with sporadic Creutzfeldt-Jakob disease.
克雅氏病是人类朊病毒病最常见的形式。一名57岁女性从当地医院转入我院，她因意识障碍和惊厥性癫痫发作在当地医院接受了两周治疗，病情进展为难治性癫痫持续状态。脑电图显示弥漫性棘波复合波放电，并出现非惊厥性癫痫持续状态。代谢性脑病和副肿瘤综合征的病因被排除。临床特征以及包括脑电图、脑脊液生物标志物和磁共振成像在内的诊断程序结果表明，该患者极有可能患有散发性克雅氏病。
