Fišerová B, Kubiczková L, Sevčíková S, Hájek R
Babakova myelomova supina, Ustav patologicke fyziologie, Brno.
Klin Onkol. 2012;25(4):234-40.
Multiple myeloma is a hematooncological disease characterized by malignant proliferation of plasma cells. These cells accumulate in the bone marrow where they suppress physiological hematopoiesis; at the same time, these cells interact with a wide variety of cytokines, growth factors and adhesion molecules. It is obvious that the bone marrow microenvironment plays an important role in disease pathogenesis as well as treatment resistance.
多发性骨髓瘤是一种血液肿瘤性疾病，其特征为浆细胞恶性增殖。这些细胞在骨髓中积聚，抑制生理性造血；同时，这些细胞与多种细胞因子、生长因子和黏附分子相互作用。很明显，骨髓微环境在疾病发病机制以及治疗耐药性方面都起着重要作用。
