磁共振成像在铁过载评估中的应用：对比分析 MRI、超声心动图和血清铁蛋白水平在重型β-地中海贫血患者中的应用。
Magnetic resonance imaging in the evaluation of iron overload: a comparison of MRI, echocardiography and serum ferritin level in patients with β-thalassemia major.
机构信息
Department of Pediatric Hematology/Oncology, Mofid Children's Hospital, Shahid Beheshti Medical University, Tehran, Iran.
出版信息
Clin Imaging. 2012 Sep-Oct;36(5):483-8. doi: 10.1016/j.clinimag.2011.11.029. Epub 2012 Jun 8.
PURPOSE
This study aimed to evaluate iron levels in cardiac and hepatic tissues using magnetic resonance imaging (MRI) T2*.
METHODS
Cardiac and hepatic MRI was performed for 93 patients with β-thalassemia major.
RESULTS
Cardiac T2* was in the range of 2.9-56.6 ms. Myocardial siderosis was detected in 44% of patients; 25 patients had moderate and severe siderosis with serum ferritin level (SFL) of 576-10,284 ng/ml. There was a significant correlation between SFL and cardiac T2* (p<.001).
CONCLUSIONS
The effective role of MRI as a noninvasive producible method in measurement of iron concentration in tissues is not accessible with conventional techniques.
目的
本研究旨在使用磁共振成像（MRI）T2*评估心脏和肝脏组织中的铁含量。
方法
对 93 例重型β-地中海贫血患者进行心脏和肝脏 MRI 检查。
结果
心脏 T2* 值范围为 2.9-56.6 ms。44%的患者存在心肌含铁血黄素沉着症；25 例患者存在中重度铁过载，血清铁蛋白（SFL）水平为 576-10284ng/ml。SFL 与心脏 T2* 呈显著相关（p<.001）。
结论
MRI 作为一种非侵入性、可重复的组织铁浓度测量方法，其有效性目前无法通过常规技术实现。
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