重型β地中海贫血患者血清铁蛋白水平与心脏和肝脏T2*加权磁共振成像的相关性
Association between serum ferritin level, cardiac and hepatic T2-star MRI in patients with major β-thalassemia.
作者信息
Eghbali A, Taherahmadi H, Shahbazi M, Bagheri B, Ebrahimi L
机构信息
Pediatric Hematologist & Oncologist, Department of Pediatrics, Arak University of Medical Sciences, Arak- Iran.
Department of Pediatrics, Arak University of Medical Sciences, Arak- Iran.
出版信息
Iran J Ped Hematol Oncol. 2014;4(1):17-21. Epub 2014 Feb 20.
BACKGROUND
Frequent blood transfusion is often associated with iron overload. Proper use of iron chelators to treat iron overload requires an accurate measurement of iron levels. Magnetic resonance T2-star (T2* MRI) can measure iron level in the heart and liver. Our goal was to see whether an association exists between serum ferritin level and T2* MRI in patients with major beta thalassemia.
MATERIALS AND METHODS
Sixty patients with a diagnosis of major beta thalassemia were enrolled in the study. They were older than five years old and needed regular transfusion. Cardiac and hepatic T2*MRI and mean serum ferritin levels were measured within 3 months.
RESULTS
No significant correlation was observed between serum ferritin level and cardiac T2MRI (p=0.361, r=-0.120).However, a significant correlation was observed between serum ferritin and liver T2MRI (p=0.021, r=-0.297).
CONCLUSION
Our results showed an association between hepatic T2*MRI and serum ferritin level.
背景
频繁输血常与铁过载相关。正确使用铁螯合剂治疗铁过载需要准确测量铁水平。磁共振T2*（T2MRI）可测量心脏和肝脏中的铁水平。我们的目标是观察重型β地中海贫血患者血清铁蛋白水平与T2MRI之间是否存在关联。
材料与方法
60例诊断为重型β地中海贫血的患者纳入本研究。他们年龄超过5岁，需要定期输血。在3个月内测量心脏和肝脏的T2*MRI以及平均血清铁蛋白水平。
结果
血清铁蛋白水平与心脏T2MRI之间未观察到显著相关性（p = 0.361，r = -0.120）。然而，血清铁蛋白与肝脏T2MRI之间观察到显著相关性（p = 0.021，r = -0.297）。
结论
我们的结果显示肝脏T2*MRI与血清铁蛋白水平之间存在关联。
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