L-脯氨酸催化的吡咯并[2,3,4-kl]吖啶-1-酮衍生物的高效合成。

An efficient synthesis of pyrrolo[2,3,4-kl]acridin-1-one derivatives catalyzed by L-proline.

机构信息

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.

出版信息

Org Lett. 2012 Sep 7;14(17):4598-601. doi: 10.1021/ol302058g. Epub 2012 Aug 24.

DOI:10.1021/ol302058g

PMID:22920713

Abstract

An efficient domino approach for the synthesis of novel pyrrolo[2,3,4-kl]acridin-1-one derivatives has been established. This reaction represents the first facile conversion of an isatin to a pyrrolo[2,3,4-kl]acridin-1-one via a C-N bond cleavage reaction without the need for a multistep reaction process.

摘要

建立了一种高效的多米诺反应方法，用于合成新型吡咯并[2,3,4-kl]吖啶-1-酮衍生物。该反应代表了首例通过 C-N 键断裂反应，无需多步反应过程，即可将色酮转化为吡咯并[2,3,4-kl]吖啶-1-酮的简便转化。