Key Laboratory of Biological Cancer Therapy of Jiangsu Province, Xuzhou Medical College, Xuzhou 221004, China.
Molecules. 2012 Nov 22;17(12):13856-63. doi: 10.3390/molecules171213856.
A series of 4-aryl-6-methyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-2,5(6H)-diones were synthesized via the three-component reactions of aromatic aldehydes, 4-hydroxy-1-methylquinolin-2(1H)-one, and Meldrum's acid catalyzed by L-proline. The structures of the products were identified by spectroscopic analysis. A mechanism for this three-component reaction catalyzed by L-proline was proposed.
一系列 4-芳基-6-甲基-3,4-二氢-2H-吡喃并[3,2-c]喹啉-2,5(6H)-二酮通过芳香醛、4-羟基-1-甲基喹啉-2(1H)-酮和 Meldrum's 酸与 L-脯氨酸的三组分反应合成。通过光谱分析鉴定了产物的结构。提出了 L-脯氨酸催化的这种三组分反应的机理。
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