Freckmann Guido, Pleus Stefan, Haug Cornelia, Bitton Gabriel, Nagar Ron
Institute for Diabetes-Technology GmbH, Ulm, Germany.
J Diabetes Sci Technol. 2012 Jul 1;6(4):780-5. doi: 10.1177/193229681200600407.
The absorption profile of rapid-acting insulin analogs delivered subcutaneously is slow compared with physiological insulin. Shorter time to peak and shorter duration of insulin action are important steps toward reducing high postprandial blood glucose concentrations in diabetes therapy and are critical for the development of a closed-loop insulin delivery system. Many attempts have been made to develop more rapid-acting insulins. Since the 1950s, different approaches, such as jet injectors and sprinkler needles, which try to increase the absorption areas of injected insulin, have been developed; however, none of them are commonly used in diabetes therapy. Massage and heat increase tissue blood perfusion and, thereby, the absorption of subcutaneously applied insulin. The main focus of this article is a novel device that allows local application of heat to human skin. The device can be connected to a regular insulin pump. This device could demonstrate a significant effect on insulin absorption and postprandial glucose excursions in multiple clinical trials.
与生理胰岛素相比，皮下注射速效胰岛素类似物的吸收曲线较为缓慢。缩短达峰时间和缩短胰岛素作用持续时间是降低糖尿病治疗中餐后高血糖浓度的重要步骤，对于闭环胰岛素输送系统的开发至关重要。人们已进行了许多尝试来开发作用更快的胰岛素。自20世纪50年代以来，已开发出不同的方法，如喷射注射器和喷雾针，试图增加注射胰岛素的吸收面积；然而，它们都未在糖尿病治疗中普遍使用。按摩和热敷可增加组织血液灌注，从而促进皮下应用胰岛素的吸收。本文的主要重点是一种可对人体皮肤进行局部加热的新型装置。该装置可连接到常规胰岛素泵。在多项临床试验中，该装置可对胰岛素吸收和餐后血糖波动产生显著影响。
