Robert Virginie, Triffaux Emily, Savignac Magali, Pelletier Lucette
Inserm U1043, centre de physiopathologie de Toulouse Purpan, place du Docteur Baylac, BP 3028, 31024 Toulouse Cedex 3, France.
Med Sci (Paris). 2012 Aug-Sep;28(8-9):773-9. doi: 10.1051/medsci/2012288020. Epub 2012 Aug 22.
Calcium signaling is essential for all the functions of T lymphocytes, including those of Th2 cells. Th2 lymphocytes producing interleukins 4, 5 and 13 orchestrate allergic diseases including asthma. T-cell activation induces an influx of Ca(2+) from the external medium through ORAI calcium channels although other calcium channels are likely to be involved. Among them, voltage-gated calcium (Ca(v)1) channels have been reported in some T-cell subsets including Th2 cells. The inhibition of Ca(v)1 channels abrogates T-cell receptor-driven calcium influx and interleukin production by Th2 cells. From a therapeutic point of view, the inhibition of Ca(v)1 channels prevents Th2-dependent experimental allergic asthma. In this review, we will discuss the singularities of calcium responses depending upon the T-cell subset and its state of activation.
钙信号传导对于T淋巴细胞的所有功能至关重要，包括Th2细胞的功能。产生白细胞介素4、5和13的Th2淋巴细胞引发包括哮喘在内的过敏性疾病。T细胞活化会诱导Ca(2+)从细胞外介质通过ORAI钙通道流入，尽管可能还涉及其他钙通道。其中，电压门控钙（Ca(v)1）通道已在包括Th2细胞在内的一些T细胞亚群中被报道。抑制Ca(v)1通道可消除T细胞受体驱动的钙内流以及Th2细胞产生的白细胞介素。从治疗角度来看，抑制Ca(v)1通道可预防Th2依赖性实验性过敏性哮喘。在本综述中，我们将讨论取决于T细胞亚群及其活化状态的钙反应的独特性。
