School of Biomedical and Health Sciences, Victoria University, St Albans 3021, Australia.
Trends Mol Med. 2012 Sep;18(9):544-54. doi: 10.1016/j.molmed.2012.07.001. Epub 2012 Aug 21.
Netrin-1 is a well-characterised chemoattractant involved in neuronal guidance in the developing enteric nervous system (ENS), but it is also a regulator of tumorigenesis. Two of its well-characterised receptors, deleted in colorectal cancer (DCC) and uncoordinated-5 homolog (UNC-5H), belong to a family of dependence receptors that transmit either pro- or anti-apoptosis signals depending on the availability of ligand, in this case netrin-1. This review summarises these two effects of netrin-1 and highlights the additional research needed information about to allow better utilisation of netrin-1 as a therapeutic target for axonal regeneration in the context of colorectal cancer.
Netrin-1 是一种特征明确的趋化因子，参与了发育中的肠神经系统（ENS）中的神经元导向，但它也是肿瘤发生的调节剂。其两个特征明确的受体，结直肠癌缺失（DCC）和非协调-5 同源物（UNC-5H），属于一组依赖受体家族，根据配体（在这种情况下是 netrin-1）的可用性，传递促凋亡或抗凋亡信号。本文综述了 netrin-1 的这两种作用，并强调了需要进一步研究的信息，以便更好地将 netrin-1 用作结直肠癌中轴突再生的治疗靶点。
