半乳糖凝集素-1 对神经保护作用？
Galectin-1 for neuroprotection?
机构信息
Glycobiology Unit, Tumor Microenvironment Program, Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
出版信息
Immunity. 2012 Aug 24;37(2):187-9. doi: 10.1016/j.immuni.2012.08.006.
PMID:22921113
Abstract
Classically activated microglia (M1) are believed to play a key role in neuronal degeneration in multiple sclerosis (MS). In this issue of Immunity, Starossom et al. (2012) show that Galectin-1 exerts a neuroprotective function through glycosylation-dependent inactivation with M1 cells.
摘要
经典激活的小胶质细胞（M1）被认为在多发性硬化症（MS）中神经元变性中发挥关键作用。在本期《免疫》中，Starossom 等人（2012）表明半乳糖凝集素-1 通过与 M1 细胞的糖基化依赖性失活发挥神经保护功能。
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