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[帕金森病的影像学非运动症状]

[Imaging non motor signs in Parkinson's disease].

作者信息

Thobois S, Ballanger B, Poisson A, Broussolle E

机构信息

CNRS, UMR 5229, centre de neurosciences cognitives, Bron cedex, France.

出版信息

Rev Neurol (Paris). 2012 Aug-Sep;168(8-9):576-84. doi: 10.1016/j.neurol.2012.05.007. Epub 2012 Aug 24.

Abstract

Parkinson's disease is mainly considered as a motor disorder defined by a motor triad. However, various non-motor manifestations may be encountered in Parkinson's disease, including hyposmia, pain, fatigue, sleep disorders, cognitive and behavioral disorders. The pathophysiology of these signs is complex, not univocal and remains poorly understood. Functional imaging techniques either by positron emission tomography, single photon emission tomography or functional magnetic resonance imaging provide an invaluable opportunity to better understand the pathophysiology of these signs. In this paper, we present a review of the recent advances provided by functional imaging in this area.

摘要

帕金森病主要被视为一种由运动三联征定义的运动障碍。然而,帕金森病可能会出现各种非运动症状,包括嗅觉减退、疼痛、疲劳、睡眠障碍、认知和行为障碍。这些症状的病理生理学很复杂,并非单一原因,而且仍未被充分理解。通过正电子发射断层扫描、单光子发射断层扫描或功能磁共振成像等功能成像技术,为更好地理解这些症状的病理生理学提供了宝贵的机会。在本文中,我们对功能成像在该领域的最新进展进行了综述。

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