Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel.
Exp Neurol. 2013 Jul;245:52-9. doi: 10.1016/j.expneurol.2012.07.023. Epub 2012 Aug 23.
In the normal brain beta band oscillatory activity has been associated with retaining of ongoing motor activities. In Parkinson's disease, enhanced beta band oscillatory activity is displayed across the cortico-basal ganglia pathway and is one of the prominent neurophysiological phenomena associated with the disorder. Intraoperative and postoperative recordings of neural activity in patients undergoing stereotactic neurosurgery combined with studies in animal models of parkinsonism have led to the accumulation of complementary data regarding these oscillations. In this review we address some of the key issues facing researchers in the field. These issues encompass existing agreements as well as open debates in modern studies of beta band oscillations, including their defining characteristics, links to clinical symptoms and the functional properties of their formation and effects on behavior. We address these questions by comparing and contrasting the results of neurophysiological observations in human patients, MPTP primate model and 6-OHDA rat model with conceptual and computational models of the normal and parkinsonian basal ganglia. Defining a unifying scheme of beta band oscillations and their relation to neurophysiological, functional and clinical phenomena will enable future targeting of these oscillations for both diagnosis and treatment of Parkinson's disease.
在正常大脑中，β波段的振荡活动与维持进行中的运动活动有关。在帕金森病中，增强的β波段振荡活动在皮质基底节通路中显示出来，是与该疾病相关的突出神经生理现象之一。对接受立体定向神经外科手术的患者进行术中及术后神经活动记录，并结合帕金森病动物模型的研究，为这些振荡积累了补充数据。在这篇综述中，我们讨论了该领域研究人员面临的一些关键问题。这些问题包括现代β波段振荡研究中的现有共识以及开放性争论，包括其定义特征、与临床症状的联系以及其形成的功能特性及其对行为的影响。我们通过比较和对比人类患者、MPTP 灵长类动物模型和 6-OHDA 大鼠模型的神经生理学观察结果，以及正常和帕金森基底神经节的概念和计算模型，来回答这些问题。定义一个统一的β波段振荡方案及其与神经生理、功能和临床现象的关系，将使我们能够针对这些振荡进行帕金森病的诊断和治疗。
