Department of Pathology, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
FEBS Lett. 2012 Sep 21;586(19):3142-9. doi: 10.1016/j.febslet.2012.08.015. Epub 2012 Aug 23.
The Bcl-2 family proteins plays a central role in apoptosis. The pro- or anti-apoptotic activities of Bcl-2 family are dependent on the Bcl-2 homology (BH) regions. Bcl-rambo, a new pro-apoptotic member, is unusual in that its pro-apoptotic activity is independent of its BH domains. However, the mechanism underlying Bcl-rambo-induced apoptosis is largely unknown. Mitochondrial localization is indispensable for the pro-apoptotic function of Bcl-rambo. Bcl-rambo interacts physically with the adenine nucleotide translocator (ANT), suppresses the ADT/ATP-dependent translocation activity of ANT. Collectively, our data indicate Bcl-rambo is a pro-apoptotic member of the Bcl-2 family, induces the permeability transition via interaction with ANT.
Bcl-2 家族蛋白在细胞凋亡中起着核心作用。Bcl-2 家族的促凋亡或抗凋亡活性取决于 Bcl-2 同源（BH）区。Bcl-rambo 是一种新的促凋亡成员，其促凋亡活性不依赖于其 BH 结构域，这很不寻常。然而，Bcl-rambo 诱导细胞凋亡的机制在很大程度上尚不清楚。线粒体定位对于 Bcl-rambo 的促凋亡功能是必不可少的。Bcl-rambo 与腺嘌呤核苷酸转位酶（ANT）发生物理相互作用，抑制 ANT 的 ADT/ATP 依赖性转运活性。总之，我们的数据表明 Bcl-rambo 是 Bcl-2 家族的促凋亡成员，通过与 ANT 的相互作用诱导通透性转换。
