UMR BGPI, INRA-CIRAD-SupAgro, TA-A54K, Campus International de Baillarguet, 34398 Montpellier Cedex 05, France.
Curr Opin Virol. 2012 Oct;2(5):546-55. doi: 10.1016/j.coviro.2012.08.001. Epub 2012 Aug 22.
Despite rapidly growing to immense sizes, virus populations suffer repeated severe bottlenecks, both within hosts and when transmitted from host to host. The potential effect of bottlenecks has been theoretically and experimentally documented, but formal estimations of their actual sizes in natural situations are scarce. Bottlenecks during colonization of organs and during transmission are influenced by those occurring at the cellular level. The study of the multiplicity of cellular infection (MOI) thus appears central, and this trait may be differentially regulated by different virus species. The values of MOI and their putative regulation deserve important future efforts, in order to disentangle the complex interactions between the control of gene copy numbers and the populations dynamics/genetics of viruses.
尽管病毒种群迅速生长到巨大的规模，但它们在宿主内部和从宿主传播到宿主时都会经历反复的严重瓶颈。瓶颈的潜在影响在理论和实验上都有记录，但在自然情况下，对其实际规模的正式估计却很少。在器官定植和传播过程中的瓶颈受到细胞水平发生的瓶颈的影响。因此，细胞感染多重性（MOI）的研究显得至关重要，而这种特征可能由不同的病毒物种差异调控。MOI 的值及其潜在的调控值得未来做出重要努力，以便厘清基因拷贝数的控制与病毒的种群动态/遗传学之间的复杂相互作用。
