成纤维细胞生长因子 23：现状与未来方向。
Fibroblast growth factor 23: state of the field and future directions.
机构信息
Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
出版信息
Trends Endocrinol Metab. 2012 Dec;23(12):610-8. doi: 10.1016/j.tem.2012.07.002. Epub 2012 Aug 24.
Abstract
Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates and is regulated by blood levels of phosphate and active vitamin D. Post-translational glycosylation by the enzyme GALNT3 and subsequent processing by furin have been demonstrated to be a regulated process that plays a role in regulating FGF23 levels. In physiologic states, FGF23 signaling is mediated by an FGF receptor and the coreceptor, Klotho. Recent work identifying a role for iron/hypoxia pathways in FGF23 physiology and their implications are discussed. Beyond its importance in primary disorders of mineral metabolism, recent work implicates FGF23 in renal disease-associated morbidity, as well as possible roles in cardiovascular disease and skeletal fragility.
摘要
成纤维细胞生长因子 23（FGF23）是一种骨源激素，调节血液中磷酸盐和活性维生素 D 的水平，并受其调节。酶 GALNT3 的翻译后糖基化和随后的弗林蛋白酶处理已被证明是一种调节过程，在调节 FGF23 水平中发挥作用。在生理状态下，FGF23 信号通过 FGF 受体和辅助受体 Klotho 介导。最近的工作确定了铁/缺氧途径在 FGF23 生理学中的作用及其意义。除了在原发性矿物质代谢紊乱中的重要性外，最近的研究还表明 FGF23 与肾脏疾病相关的发病率有关，以及在心血管疾病和骨骼脆弱性中的可能作用。
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