Bennewitz Christian, Kuwert Torsten, Han Jingfeng, Ritt Philipp, Hahn Dieter, Thimister Willie, Hornegger Joachim, Uder Michael, Schmidt Daniela
Clinic of Nuclear Medicine, University of Erlangen-Nürnberg, Erlangen, Germany.
Nucl Med Commun. 2012 Nov;33(11):1153-9. doi: 10.1097/MNM.0b013e32835839cc.
The purpose of this study was to investigate the anatomical accuracy of hardware-based single-photon emission computed tomography/computed tomography (SPECT/CT) registration in the upper abdomen and neck.
The database consisted of 90 patients referred for SPECT/CT for diagnostic workup of either thyroid/parathyroid disease (n=46) or abdominal neuroendocrine tumours (n=44). In the first group, 99mTc-MIBI was used as the tracer and in the second 123I-metaiodobenzylguanidine (n=13), 111In-octreotide (n=28) or 99mTc-octreotide (n=3). For predefined structures represented by both modalities, the distances between the centres of gravity of their CT and SPECT representation were determined in a semiautomated manner. In cervical data sets, this analysis was performed for the submandibular salivary glands (n=92) and in abdominal data sets for 69 neoplastic foci.
The mean distances were 5.7 ± 2.0 mm (range: 1.84-9.67 mm) in the neck and 6.8 ± 3.3 mm (range: 1.4-19.7 mm) in the abdomen. In 42 out of 92 of the cervical and 40 out of 69 of the abdominal data sets at least one of the X-direction-determined, Y-direction-determined, and Z-direction-determined distances was greater than the SPECT pixel width of 4.6 mm.
The anatomical accuracy of hardware-based SPECT/CT fusion depends also on the region of the body studied. For example, in the neck and upper abdomen the accuracy is lower than in the lower lumbar spine. In clinical routine, SPECT/CT data sets acquired for the neck and upper abdomen should be regularly checked and corrected for SPECT/CT misalignment. This is, in particular, important when CT-based corrections of SPECT involving pixelwise data integration such as for attenuation correction are made.
本研究旨在调查基于硬件的单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）在上腹部和颈部配准的解剖学准确性。
数据库包含90例因甲状腺/甲状旁腺疾病（n = 46）或腹部神经内分泌肿瘤（n = 44）接受SPECT/CT诊断检查的患者。在第一组中，使用99mTc-MIBI作为示踪剂，在第二组中，使用123I-间碘苄胍（n = 13）、111In-奥曲肽（n = 28）或99mTc-奥曲肽（n = 3）。对于两种模态均显示的预定义结构，以半自动方式确定其CT和SPECT图像重心之间的距离。在颈部数据集中，对下颌下唾液腺（n = 92）进行此分析，在腹部数据集中，对69个肿瘤病灶进行此分析。
颈部的平均距离为5.7±2.0毫米（范围：1.84 - 9.67毫米），腹部为6.8±3.3毫米（范围：1.4 - 19.7毫米）。在92例颈部数据集中的42例以及69例腹部数据集中的40例中，至少一个在X方向、Y方向和Z方向确定的距离大于SPECT像素宽度4.6毫米。
基于硬件的SPECT/CT融合的解剖学准确性还取决于所研究的身体部位。例如，在颈部和上腹部，准确性低于下腰椎。在临床常规中，应为颈部和上腹部采集的SPECT/CT数据集定期检查并校正SPECT/CT的错位。特别是在进行基于CT的SPECT校正（如涉及逐像素数据积分的衰减校正）时，这一点尤为重要。
