阿仑膦酸盐与低强度脉冲超声联合治疗可增加老年大鼠松质骨截骨部位的骨密度：一项初步研究。

Combined treatment of alendronate and low-intensity pulsed ultrasound (LIPUS) increases bone mineral density at the cancellous bone osteotomy site in aged rats: a preliminary study.

作者信息

Aonuma H, Miyakoshi N, Kasukawa Y, Kamo K, Sasaki H, Tsuchie H, Segawa T, Shimada Y

机构信息

Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

出版信息

JNMA J Nepal Med Assoc. 2011 Oct-Dec;51(184):171-5.

PMID:22922896

Abstract

INTRODUCTION

During fracture healing, alendronate encourages callus volume by inhibiting bone resorption, whereas low-intensity pulsed ultrasound (LIPUS) enhances bone regeneration by promoting an anabolic response.

METHODS

In the present study, 9-month-old Sprague-Dawley rats, with a unilateral proximal tibial osteotomy, were treated with alendronate (daily, 1 µg/kg) plus sham-LIPUS (n = 14), saline plus LIPUS (20 min/day) (n = 18), alendronate plus LIPUS (n = 16), or saline plus sham-LIPUS as a control (n = 13) for 4 weeks. The rats were then examined for changes in bone mineral density (BMD) during metaphyseal bone repair.

RESULTS

The combined therapy significantly increased BMD at the osteotomy site at 4 weeks (p < 0.001) compared with the control, without affecting the contralateral, non-osteotomized tibia. Both alendronate and LIPUS alone also exerted a positive, albeit less, effect on BMD in the affected limb (p < 0.001 and p = 0.006, respectively).

CONCLUSION

Alendronate and LIPUS cooperate to enhance BMD during metaphyseal bone healing.

摘要

引言

在骨折愈合过程中，阿仑膦酸盐通过抑制骨吸收来增加骨痂体积，而低强度脉冲超声（LIPUS）则通过促进合成代谢反应来增强骨再生。

方法

在本研究中，对9个月大的单侧胫骨近端截骨的Sprague-Dawley大鼠，分别用阿仑膦酸盐（每日1μg/kg）加假LIPUS（n = 14）、生理盐水加LIPUS（每天20分钟）（n = 18）、阿仑膦酸盐加LIPUS（n = 16）或生理盐水加假LIPUS作为对照（n = 13）进行治疗，为期4周。然后检查大鼠干骺端骨修复过程中骨密度（BMD）的变化。