James Buchanan Brady Department of Urology, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.
Curr Urol Rep. 2012 Dec;13(6):413-9. doi: 10.1007/s11934-012-0276-7.
In this review, we present the evidence on the safety and efficacy of anticholinergic therapy for men with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) and emphasize the data published over the past year. This review discusses two classes of medications whose mechanism of action attenuates the effect of acetylcholine on the LUT: anticholinergics and botulinum toxin. We review the randomized controlled trials that investigate the efficacy and side effects of anticholinergics when used in men with LUTS secondary to BPH. We emphasize new studies and developments that have been made in the past year.
在这篇综述中，我们介绍了抗胆碱能治疗对良性前列腺增生（BPH）引起的下尿路症状（LUTS）男性的安全性和有效性的证据，并强调了过去一年发表的数据。本文讨论了两类药物，其作用机制减弱了乙酰胆碱对 LUT 的作用：抗胆碱能药物和肉毒毒素。我们综述了调查抗胆碱能药物治疗 BPH 引起的 LUTS 男性的疗效和副作用的随机对照试验。我们强调了过去一年取得的新研究和进展。
