State Key Laboratory of Natural Medicines, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing 210009, PR China.
Mol Med Rep. 2012 Nov;6(5):1121-5. doi: 10.3892/mmr.2012.1047. Epub 2012 Aug 24.
Previous research has shown that the Dwarf lilyturf tuber has antitumor effects. The antitumor ability of DT-13, a saponin monomer isolated from the roots of the Dwarf lilyturf tuber, is discussed in this study. The results showed that DT-13 inhibited the proliferation, adhesion and invasion of MDA-MB-435 cells. DT-13 decreased the excretion and expression of MMP-2/9. Furthermore, DT-13 inhibited the phosphorylation of p38 in MDA-MB-435 cells. In conclusion, the results suggest that DT-13 possesses anticancer and antimetastatic properties by inhibiting the invasion of cancer cells.
先前的研究表明，山麦冬块根具有抗肿瘤作用。本研究探讨了从山麦冬块根中分离得到的皂苷单体 DT-13 的抗肿瘤能力。结果表明，DT-13 抑制 MDA-MB-435 细胞的增殖、黏附和侵袭。DT-13 降低了 MMP-2/9 的排泄和表达。此外，DT-13 抑制了 MDA-MB-435 细胞中 p38 的磷酸化。综上所述，研究结果表明 DT-13 通过抑制癌细胞的侵袭发挥抗癌和抗转移作用。
