Macut Natasa Djukić, Malobabić Slobodan, Stefanović Natalija, Mandić Predrag, Filipović Tatjana, Maliković Aleksandar, Saranović Milena
Faculty of Medicine, University of Pristina-Kosovska Mitrovica, Kosovska Mitrovica, Serbia.
Vojnosanit Pregl. 2012 Aug;69(8):681-5.
BACKGROUND/AIM: Both superior parietal lobule (SPL) of dorsolateral hemispheric surface and precuneus (PEC) of medial surface are the parts of posterior parietal cortex. The aim of this study was to determine the numerical density (Nv) of pyramidal neurons in the layer V of SPL and PEC and their potential differences.
From 20 (40 hemispheres) formaline fixed human brains (both sexes; 27- 65 years) tissue blocks from SPL and PEC from the left and right hemisphere were used. According to their size the brains were divided into two groups, the group I with the larger left (15 brains) and the group II with the larger right hemisphere (5 brains). Serial Nissl sections (5 microm) of the left and right SPL and PEC were used for stereological estimation of Nv of the layer V pyramidal neurons.
Nv of pyramidal neurons in the layer V in the left SPL of brains with larger left hemispheres was significantly higher than in the left SPL of brains with larger right hemisphere. Comparing sides in brains with larger left hemisphere, the left SPL had higher Nv than the right one, and then the left PEC, and the right SPL had significantly higher Nv than the right PEC. Comparing sides in brains with the larger right hemisphere, the left SPL had significantly higher Nv than left PEC, but the right SPL had significantly higher Nv than left SPL and the right PEC.
Generally, there is an inverse relationship of Nv between the medial and lateral areas of the human posterior parietal cortex. The obtained values were different between the brains with larger left and right hemispheres, as well as between the SPL and PEC. In all the comparisons the left SPL had the highest values of Nv of pyramidal neurons in the layer V (4771.80 mm(-3)), except in brains with the larger right hemisphere.
背景/目的：背外侧半球表面的顶上小叶（SPL）和内侧面的楔前叶（PEC）均为顶叶后皮质的组成部分。本研究旨在确定顶上小叶和楔前叶第V层锥体细胞的数量密度（Nv）及其潜在差异。
使用20个（40个半球）用福尔马林固定的人脑（男女不限；27 - 65岁），取左右半球的顶上小叶和楔前叶的组织块。根据大脑大小将其分为两组，I组左半球较大（15个大脑），II组右半球较大（5个大脑）。对左右顶上小叶和楔前叶的连续尼氏切片（5微米）进行第V层锥体细胞数量密度的体视学估计。
左半球较大的大脑中，左侧顶上小叶第V层锥体细胞的数量密度显著高于右半球较大的大脑中左侧顶上小叶的数量密度。在左半球较大的大脑中比较两侧，左侧顶上小叶的数量密度高于右侧，其次是左侧楔前叶，右侧顶上小叶的数量密度显著高于右侧楔前叶。在右半球较大的大脑中比较两侧，左侧顶上小叶的数量密度显著高于左侧楔前叶，但右侧顶上小叶的数量密度显著高于左侧顶上小叶和右侧楔前叶。
一般来说，人类顶叶后皮质的内侧和外侧区域的数量密度呈负相关。左右半球较大的大脑之间以及顶上小叶和楔前叶之间获得的值有所不同。在所有比较中，除了右半球较大的大脑外，左侧顶上小叶第V层锥体细胞数量密度的值最高（4771.80 mm⁻³）。
