Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, 1405 Clifton Road NE, Atlanta, GA 30322, USA.
Br J Haematol. 2012 Oct;159(2):211-5. doi: 10.1111/bjh.12019. Epub 2012 Aug 28.
We report results of a pilot study of high-dose vitamin D in sickle cell disease (SCD). Subjects were given a 6-week course of oral high-dose cholecalciferol (4000-100 000 IU per week) or placebo and monitored prospectively for a period of six months. Vitamin D insufficiency and deficiency was present at baseline in 82·5% and 52·5% of subjects, respectively. Subjects who received high-dose vitamin D achieved higher serum 25-hydroxyvitamin D, experienced fewer pain days per week, and had higher physical activity quality-of-life scores. These findings suggest a potential benefit of vitamin D in reducing the number of pain days in SCD. Larger prospective studies with longer duration are needed to confirm these effects.
我们报告了一项关于大剂量维生素 D 在镰状细胞病（SCD）中的疗效的初步研究结果。受试者接受了为期 6 周的口服大剂量胆钙化醇（每周 4000-100000IU）或安慰剂治疗，并前瞻性监测了 6 个月。基线时，分别有 82.5%和 52.5%的受试者存在维生素 D 不足和缺乏。接受大剂量维生素 D 的受试者血清 25-羟维生素 D 水平更高，每周疼痛天数更少，身体活动生活质量评分更高。这些发现表明维生素 D 可能有助于减少 SCD 患者的疼痛天数。需要进行更大规模、更长时间的前瞻性研究来证实这些效果。
