钯催化的 C-H 活化和选择性 C(sp2)-C(sp2)键断裂实现 2-芳基吡啶与α-二酮的直接碳酰化反应。
Direct carbo-acylation reactions of 2-arylpyridines with α-diketones via Pd-catalyzed C-H activation and selective C(sp2)-C(sp2) cleavage.
机构信息
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, PR China.
出版信息
Org Lett. 2012 Sep 7;14(17):4594-7. doi: 10.1021/ol3020557. Epub 2012 Aug 27.
PMID:22924751
Abstract
An efficient carbo-acylation reaction of 2-arylpyridines with α-diketones via Pd-catalyzed C-H bond activation and C-C bond cleavage in the presence of TBHP was developed that generated aryl ketones in good yields. The highly selective formation of aryl ketones was observed when 2-arylpyridines reacted with aromatic/aliphatic α-diketones.
摘要
Pd 催化的 C-H 键活化和 C-C 键断裂促进的 2-芳基吡啶与 α-二酮的高效碳酰化反应在 TBHP 的存在下得以发展，该反应以良好的收率生成芳基酮。当 2-芳基吡啶与芳香族/脂肪族 α-二酮反应时，观察到芳基酮的高选择性形成。
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