Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Clin Exp Dermatol. 2013 Mar;38(2):156-9. doi: 10.1111/j.1365-2230.2012.04437.x. Epub 2012 Aug 27.
Idiopathic pure sudomotor failure (IPSF) is a subgroup of acquired idiopathic generalized anhidrosis, which is characterized by early age of onset, acute or sudden onset, concomitant sharp pain or cholinergic urticaria over the entire body, absence of autonomic dysfunction other than generalized anhidrosis, raised serum IgE level, and marked response to steroid. The aetiology of IPSF is still not well understood, but is thought to be caused by interference in cholinergic transmission in the eccrine glands of skin. IPSF after viral infection has rarely been reported in the literature. We describe a patient who developed generalized anhidrosis and cholinergic urticaria accompanied by heat intolerance after infectious mononucleosis infection. This is the first such case, to our knowledge, and the patient was successfully treated with steroid pulse therapy.
特发性单纯性汗腺功能衰竭（IPSF）是获得性特发性全身无汗症的一个亚组，其特征为发病年龄早、急性或突然起病、全身伴有剧烈疼痛或胆碱能性荨麻疹、除全身无汗外无自主神经功能障碍、血清 IgE 水平升高、对类固醇有明显反应。IPSF 的病因尚不清楚，但据认为是由皮肤外分泌汗腺的胆碱能传递干扰引起的。病毒感染后发生 IPSF 的情况在文献中很少报道。我们描述了一例患者在传染性单核细胞增多症感染后出现全身无汗和胆碱能性荨麻疹伴耐热性差。据我们所知，这是首例此类病例，患者经类固醇脉冲治疗后成功治愈。
